… In the periphery, endogenous mechanisms counteracting pain and inflammation arise
from interaction between leukocyte-derived opioid peptides and opioid receptors on the …

… ’s antinociceptive effects in neuropathic pain involve the upregulation of antinociceptive IL-10
expression in the rat spinal cord [26], which is consistent with our findings obtained with …

… Using the cuff model of neuropathic pain in mice, we show … μ-opioid receptor, in δ-opioid
receptor and in κ-opioid receptor … agreement with other results obtained with systemic delivery …

… Male CD-1 (aka ICR) mice from 4 to 8 weeks of age were obtained from Charles River
Laboratories (Wilmington, MA). This mouse strain is very commonly used in opioid pharmacology …

… Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced
mechanical hypersensitivity in animal models. Since neuropathic pain can also be …

… The results obtained in the first phase of the intraplantar formalin test confirmed that both
drugs … Thus, the results obtained in the present study confirmed the role of central opioidergic …

… this DOR agonist during diabetic neuropathic pain in mice. In … as well as to those obtained
by other authors showing that the … to other previous data obtained in animals with inflammatory …

… nerve was established to induce neuropathic pain in mice using the method described by …
The obtained results suggested that KMO inhibition causes a shift in the KP pathway toward …

… that dynorphin, an inhibitory opioid neuropeptide derived from the precursor prodynorphin,
is paradoxically able to promote pain and hypersensitivity via non-opioid mechanisms [140]. …

… in them and the number of closed arm entries obtained in EPM as well as on the depressive-…
spinal cord from CCI-induced neuropathic pain in mice are represented. The protein levels …